Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702808 | 0.85 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL8972057 | 0.83 | AGTR1 (0.71) | AGTR1AGTR2PPARG | |
| SCHEMBL9260166 | 0.82 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9701125 | 0.81 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL9702673 | 0.81 | AGTR1 (0.42) | AGTR1AGTR2PPARG | |
| SCHEMBL9702879 | 0.81 | AGTR1 (0.42) | AGTR1AGTR2PPARG | |
| SCHEMBL9701118 | 0.80 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL8972048 | 0.80 | AGTR1 (0.52) | AGTR1AGTR2PPARG | |
| SCHEMBL8537705 | 0.80 | AGTR1 (0.43) | AGTR1AGTR2PPARG | |
| SCHEMBL9262756 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497516-A1 | Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | claimed |
| US-5124335-A | Hypotensive agents, antiglaucoma agents | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | claimed |
| JP-5001062-A | — | — | None | — | — | JP | disclosed |
| JP-H051062-A | SUBSTITUTED PYRROLO-CONDENSED 6 MEMBERED HETEROCYCLE AS ANGIOTENSIN II ANTAGONIST | MERCK & CO INC | 1993-01-08 | — | — | JP | disclosed |
| EP-0497516-A1 | Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5124335-A | Hypotensive agents, antiglaucoma agents | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |