Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.71 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.71 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29486817 | 0.94 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL7622112 | 0.94 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL9312828 | 0.94 | AGTR1 (0.68) | AGTR1AGTR2PPARG | |
| Hydrochloric Acid SCHEMBL7841670 | 0.94 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL8972068 | 0.92 | AGTR1 (0.60) | AGTR1AGTR2LMNA | |
| SCHEMBL8972687 | 0.90 | AGTR1 (0.61) | AGTR1AGTR2LMNA | |
| SCHEMBL8972204 | 0.90 | AGTR1 (0.59) | AGTR1AGTR2PPARGLMNA | |
| SCHEMBL9847832 | 0.90 | AGTR1 (0.60) | AGTR1AGTR2LMNAPDE4APDE4B | |
| SCHEMBL9425039 | 0.88 | AGTR1 (0.59) | AGTR1AGTR2PPARGLMNA | |
| SCHEMBL9406514 | 0.88 | AGTR1 (0.70) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | claimed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |
| EP-0426021-A1 | Condensed imidazole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |