Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 9/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503950 | 0.94 | MMP3 (0.51) | MMP3ACE2MMP1CTRB1NPSR1 | |
| SCHEMBL9506811 | 0.94 | MMP3 (0.51) | MMP3ACE2MMP1CTRB1NPSR1 | |
| SCHEMBL9790866 | 0.93 | MMP3 (0.60) | MMP3ACE2MMP1MMP2 | |
| SCHEMBL9790846 | 0.93 | MMP3 (0.60) | MMP3ACE2MMP1MMP2 | |
| SCHEMBL9506857 | 0.90 | MMP3 (0.56) | MMP3ACE2MMP1CTRB1NPSR1 | |
| SCHEMBL9506869 | 0.90 | MMP3 (0.56) | MMP3ACE2MMP1CTRB1NPSR1 | |
| SCHEMBL9506066 | 0.89 | MMP3 (0.67) | MMP3ACE2MMP1CTRB1MMP2 | |
| SCHEMBL9506080 | 0.89 | MMP3 (0.67) | MMP3ACE2MMP1CTRB1MMP2 | |
| SCHEMBL10594133 | 0.87 | MMP3 (0.61) | MMP3ACE2MMP1CTRB1NPSR1 | |
| SCHEMBL10594145 | 0.87 | MMP3 (0.61) | MMP3ACE2MMP1CTRB1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-5006651-A | Rheumatic diseases, bone disorders | HOFFMAN-LA ROCHE INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |