Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.56 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506857 | 1.00 | MMP3 (0.56) | MMP3MMP1ACE2KDM4ELMNA | |
| SCHEMBL9503950 | 0.96 | MMP3 (0.51) | MMP3MMP1ACE2KDM4ELMNA | |
| SCHEMBL9506811 | 0.96 | MMP3 (0.51) | MMP3MMP1ACE2KDM4ELMNA | |
| SCHEMBL9506080 | 0.91 | MMP3 (0.67) | MMP3MMP1ACE2CTRB1MMP2 | |
| SCHEMBL9506066 | 0.91 | MMP3 (0.67) | MMP3MMP1ACE2CTRB1MMP2 | |
| SCHEMBL9503957 | 0.90 | MMP3 (0.52) | MMP3MMP1ACE2KDM4ELMNA | |
| SCHEMBL9504991 | 0.87 | MMP3 (0.45) | MMP3MMP1ACE2KDM4ELMNA | |
| SCHEMBL9790866 | 0.87 | MMP3 (0.60) | MMP3MMP1ACE2MMP2 | |
| SCHEMBL9790846 | 0.87 | MMP3 (0.60) | MMP3MMP1ACE2MMP2 | |
| SCHEMBL9790886 | 0.86 | MMP3 (0.50) | MMP3MMP1ACE2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276436-B1 | PHOSPHINIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-16 | — | — | EP | disclosed |
| US-5006651-A | Rheumatic diseases, bone disorders | HOFFMAN-LA ROCHE INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4885283-A | Phosphinic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0276436-A1 | Phosphinic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-08-03 | — | — | EP | disclosed |