Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Serotonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.64 |
| ▸ | HTR1A | P08908 | 5/20 | 0.64 |
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | HTR1B | P28222 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 3/20 | 0.64 |
| ▸ | HTR6 | P50406 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | HTR1D | P28221 | 3/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
| ▸ | HTR1E | P28566 | 2/20 | 0.64 |
| ▸ | HTR5A | P47898 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.64 |
| ▸ | HTR3B | O95264 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | HTR1F | P30939 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serotonin SCHEMBL31141325 | 0.91 | HTR2C (0.78) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL7091772 | 0.91 | HTR2C (0.78) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL7091769 | 0.91 | HTR2C (0.78) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL29042320 | 0.90 | HTR2C (0.76) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL1321606 | 0.90 | HTR2C (0.76) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL28466208 | 0.83 | HTR2C (0.83) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL28307138 | 0.82 | HTR2C (0.85) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| Serotonin SCHEMBL5833418 | 0.82 | HTR2C (0.85) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL31240192 | 0.81 | HTR1A (0.78) | HTR2CHTR1AHTR7HTR1BCYP1A2 | |
| 5-Methoxytryptamine SCHEMBL30933118 | 0.81 | HTR1A (0.78) | HTR2CHTR1AHTR7HTR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106983759-A | Treat the new compositions and method of excess proliferative disease | ALS山地有限责任公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-102098914-A | Novel compositions and methods for treating hyperproliferative diseases | ALS MOUNTAIN LLC | 2011-06-15 | — | — | CN | disclosed |
| EP-0555231-A1 | REGULATION OF NEOPLASTIC CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0547172-A1 | REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1993-06-23 | — | — | EP | disclosed |
| WO-1992004015-A2 | REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004014-A2 | REGULATION OF NEOPLASTIC CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1992-03-19 | — | — | WO | disclosed |