Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 5/20 | 0.68 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502951 | 0.86 | PNP (0.69) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL9504559 | 0.81 | HDAC6 (0.62) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL8955603 | 0.81 | PNP (1.00) | PNP | |
| SCHEMBL9502893 | 0.79 | PNP (0.69) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL9504540 | 0.78 | PNP (0.69) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL3269795 | 0.77 | ADORA2A (0.64) | HSP90AB1HSP90AA1HDAC6HDAC1HDAC4 | |
| SCHEMBL9506694 | 0.76 | PNP (0.70) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL3392706 | 0.76 | HSP90AB1 (0.72) | HSP90AB1HSP90AA1ADORA2A | |
| SCHEMBL1566036 | 0.75 | FGFR1 (0.63) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 | |
| SCHEMBL30759944 | 0.75 | FGFR1 (0.63) | PNPHSP90AB1HSP90AA1HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550574-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005180-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | disclosed |