SCHEMBL9505160

SCHEMBL9505160

CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(C)=O)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 0.68
HIF1A Q16665 5/20 0.65
CYP2C9 P11712 5/20 0.65
MEN1 O00255 4/20 0.65
CYP1A2 P05177 4/20 0.65
CYP3A4 P08684 4/20 0.65
CYP2C19 P33261 4/20 0.65
KMT2A Q03164 4/20 0.65
MAPT P10636 3/20 0.65
LMNA P02545 2/20 0.65
CYP2D6 P10635 2/20 0.65
TSHR P16473 2/20 0.65
NFKB1 P19838 2/20 0.65
THPO P40225 2/20 0.65
POLB P06746 1/20 0.65
MAPK1 P28482 1/20 0.65
GPR55 Q9Y2T6 1/20 0.65
KDM4E B2RXH2 4/20 0.62
HSD17B10 Q99714 3/20 0.62
ALDH1A1 P00352 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10699013 0.88 ADORA3 (0.64) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL10655156 0.85 ADORA3 (0.59) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL8288455 0.83 ADORA3 (0.74) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL3325205 0.83 ADORA3 (0.57) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL6954033 0.83 POLB (0.76) MEN1KMT2ALMNATSHRPOLB
SCHEMBL9502243 0.82 ADORA3 (0.73) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL20610477 0.81 ADORA3 (1.00) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL10662171 0.81 ALDH1A1 (0.58) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL10660315 0.81 ADORA3 (0.57) ADORA3HIF1ACYP2C9MEN1CYP1A2
Nitrendipine SCHEMBL20770336 0.81 HIF1A (0.76) ADORA3HIF1ACYP2C9MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458823-B1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-10-13 EP disclosed
US-5245039-A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA (IT) 1993-09-14 US disclosed
EP-0458823-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES. BOEHRINGER MANNHEIM ITALIA (IT) 1991-12-04 EP disclosed
WO-1990009376-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-23 WO disclosed
EP-0383320-A1 A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-22 EP disclosed