Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | TOP1 | P11387 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | ARG2 | P78540 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020596 | 1.00 | MAOB (0.62) | MAOBTOP1TSHRDAONAPRT | |
| SCHEMBL1984844 | 0.85 | RARA (0.55) | MAOBTSHRDAONAPRTALDH1A1 | |
| SCHEMBL1984843 | 0.85 | RARA (0.55) | MAOBTSHRDAONAPRTALDH1A1 | |
| SCHEMBL1981144 | 0.85 | RARA (0.58) | MAOBTSHRDAONAPRTALDH1A1 | |
| SCHEMBL1981146 | 0.85 | RARA (0.58) | MAOBTSHRDAONAPRTALDH1A1 | |
| SCHEMBL5805280 | 0.83 | ALDH1A1 (0.52) | TSHRALDH1A1SRD5A2NR4A1TP53 | |
| SCHEMBL5576096 | 0.83 | ALDH1A1 (0.52) | TSHRALDH1A1SRD5A2NR4A1TP53 | |
| SCHEMBL29161415 | 0.83 | NR4A2 (0.61) | MAOBSRD5A2NR4A1NR4A2NR4A3 | |
| SCHEMBL10639379 | 0.82 | NAPRT (0.57) | TSHRNAPRTALDH1A1TP53CA1 | |
| SCHEMBL10639390 | 0.82 | NAPRT (0.57) | TSHRNAPRTALDH1A1TP53CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-4757078-A | Antiinflammatory agents, psoriasis | E. R. SQUIBB & SONS, INC. (US) | 1988-07-12 | — | — | US | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |