Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670210 | 0.86 | ESR1 (0.47) | GAAKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL11745958 | 0.79 | GAA (0.61) | GAAKDM4ETSHRNFKB1TDP1 | |
| SCHEMBL4670607 | 0.78 | ESR1 (0.53) | GAAKDM4EHSD17B10MAPTTDP1 | |
| SCHEMBL27608928 | 0.78 | ESR1 (0.53) | KDM4EMAPTPOLBTHRATHRB | |
| Methane SCHEMBL10453459 | 0.78 | GAA (0.60) | GAAKDM4ETSHRNFKB1TDP1 | |
| SCHEMBL21585558 | 0.77 | AKR1B1 (0.62) | GAAKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL756841 | 0.76 | PTGS1 (0.71) | GAAKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL134713 | 0.75 | GAA (0.68) | GAAKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL11275952 | 0.75 | GAA (0.68) | GAAKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL27537426 | 0.75 | AKR1B1 (0.60) | GAAKDM4EHPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250693-A | Lipoxygenase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0547148-A1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-5208344-A | Benzothiazole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |
| WO-1992004325-A1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5084575-A | Drugs for the treatment of rhinitis, asthma and skin disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |