Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 3/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 6/20 | 0.41 |
| ▸ | WNT3 | P56703 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | TGM1 | P22735 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504084 | 0.89 | NR1H2 (0.46) | NR1H2HSD11B1STSALDH1A1 | |
| SCHEMBL9006196 | 0.88 | STS (0.52) | NR1H2HSD11B1STSF13A1TGM2 | |
| SCHEMBL9503238 | 0.88 | NR1H2 (0.46) | NR1H2TGFBR1SFRP1WNT3NR1H3 | |
| SCHEMBL10701160 | 0.88 | NR1H2 (0.46) | NR1H2TGFBR1SFRP1WNT3NR1H3 | |
| SCHEMBL9507014 | 0.88 | NR1H2 (0.46) | NR1H2TGFBR1SFRP1WNT3NR1H3 | |
| SCHEMBL9506352 | 0.87 | STS (0.53) | NR1H2TGFBR1STSALDH1A1 | |
| SCHEMBL30476432 | 0.86 | NR1H2 (0.47) | NR1H2MAPTHSD11B1TGFBR1STS | |
| SCHEMBL9505085 | 0.84 | NR1H2 (0.50) | NR1H2MAPTHSD11B1TGFBR1STS | |
| SCHEMBL29716425 | 0.79 | STS (0.59) | NR1H2MAPTTGFBR1STSSFRP1 | |
| SCHEMBL28537575 | 0.79 | TACR1 (0.44) | NR1H2MAPTHSD11B1GAANR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289911-B1 | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | disclosed |
| US-4916152-A | THROMBOXANE A2 ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-10 | — | — | US | disclosed |
| EP-0289911-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-09 | — | — | EP | disclosed |