Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | SFRP1 | Q8N474 | 5/20 | 0.43 |
| ▸ | WNT3 | P56703 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701160 | 1.00 | NR1H2 (0.46) | NR1H2NR1H3SFRP1WNT3MCL1 | |
| SCHEMBL9503238 | 1.00 | NR1H2 (0.46) | NR1H2NR1H3SFRP1WNT3MCL1 | |
| SCHEMBL9504084 | 0.90 | NR1H2 (0.46) | NR1H2MCL1 | |
| SCHEMBL9006196 | 0.89 | STS (0.52) | NR1H2MCL1 | |
| SCHEMBL9506352 | 0.89 | STS (0.53) | NR1H2TGFBR1 | |
| SCHEMBL9506263 | 0.88 | NR1H2 (0.48) | NR1H2NR1H3SFRP1WNT3TGFBR1 | |
| SCHEMBL9506275 | 0.85 | NR1H2 (0.48) | NR1H2NR1H3 | |
| SCHEMBL9024402 | 0.85 | TBXA2R (0.48) | — | |
| SCHEMBL9006144 | 0.85 | TBXA2R (0.48) | — | |
| SCHEMBL12267639 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3SFRP1WNT3MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289911-B1 | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | disclosed |
| US-4916152-A | THROMBOXANE A2 ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-10 | — | — | US | disclosed |