Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.49 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502502 | 0.93 | HDAC1 (0.53) | PLK1ACAT1HDAC1HDAC8HDAC6 | |
| SCHEMBL9503223 | 0.89 | PLK1 (0.58) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9505673 | 0.86 | ACAT1 (0.67) | PLK1ACAT1MAPTTSHRMAPK1 | |
| SCHEMBL9366112 | 0.86 | ACAT1 (0.56) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9365159 | 0.82 | CREBBP (0.65) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9365185 | 0.81 | ACAT1 (0.62) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9362195 | 0.80 | ACAT1 (0.73) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9502439 | 0.79 | MAPT (0.62) | PLK1ACAT1HDAC1HDAC8HDAC6 | |
| SCHEMBL9365907 | 0.79 | ACAT1 (0.64) | PLK1ACAT1CREBBPHDAC1HDAC8 | |
| SCHEMBL9505696 | 0.77 | ACAT1 (0.62) | PLK1ACAT1MAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543884-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ATHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |