Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL1485419 | 1.00 | — | — | |
| Piperazine SCHEMBL29044668 | 0.96 | ALDH1A1 (0.46) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL22092466 | 0.96 | ALDH1A1 (0.46) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL28015400 | 0.96 | ALDH1A1 (0.46) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Aziridine SCHEMBL64046 | 0.96 | — | — | |
| Cyclohexane SCHEMBL28639868 | 0.93 | ALDH1A1 (0.44) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Alcohol SCHEMBL27962627 | 0.89 | CXCR4 (0.60) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Cyclohexane SCHEMBL29042400 | 0.89 | ALDH1A1 (0.41) | ALDH1A1TSHRHIF1AMAPTPDE4A | |
| Aziridine SCHEMBL27979623 | 0.88 | — | — | |
| Piperazine SCHEMBL27713827 | 0.87 | ALDH1A1 (0.38) | ALDH1A1TSHRHIF1AMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225558-A1 | INHIBITORS OF RLIP76 | AVESTA76 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| EP-0338385-B1 | PROCESS FOR THE PREPARATION OF N,N'-BIS-(2-HYDROXY-ETHYL)-PIPERAZINE | Enichem Anic S.r.l. (IT) | 1993-08-04 | — | — | EP | disclosed |
| US-4945161-A | Process for the preparation of N,N'-bis-(2-hydroxy-ethyl) piperazine | ENICHEM ANIC S.P.A. (IT) | 1990-07-31 | — | — | US | disclosed |
| EP-0338385-A1 | Process for the preparation of N,N'-bis-(2-Hydroxy-ethyl)-piperazine | Enichem Anic S.r.l. (IT) | 1989-10-25 | — | — | EP | disclosed |