Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509204 | 0.91 | CNR2 (0.44) | CNR2 | |
| SCHEMBL9506842 | 0.84 | TP53 (0.53) | — | |
| SCHEMBL9509878 | 0.80 | PTPN11 (0.45) | MCL1PTPN11 | |
| SCHEMBL10411632 | 0.80 | AKR1C3 (0.57) | CNR2 | |
| SCHEMBL10412731 | 0.80 | AKR1C3 (0.57) | CNR2 | |
| Methane SCHEMBL10411635 | 0.79 | PTGS1 (0.45) | CNR2PTPN11 | |
| SCHEMBL9507021 | 0.75 | GRM2 (0.52) | — | |
| SCHEMBL4653931 | 0.75 | PTPN11 (0.67) | MCL1PTPN11KAT8 | |
| SCHEMBL223621 | 0.75 | PTPN11 (0.67) | MCL1PTPN11KAT8 | |
| SCHEMBL1576902 | 0.75 | PTPN11 (0.67) | MCL1PTPN11KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | claimed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | claimed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |