Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.45 |
| ▸ | BID | P55957 | 3/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.42 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509184 | 0.90 | MAOB (0.44) | — | |
| SCHEMBL10411832 | 0.85 | PTPN1 (0.45) | PTPN11 | |
| SCHEMBL9510360 | 0.85 | KMT2A (0.56) | — | |
| SCHEMBL10411798 | 0.84 | MTNR1A (0.47) | — | |
| SCHEMBL9510354 | 0.83 | PLA2G4B (0.55) | — | |
| SCHEMBL10411015 | 0.82 | MTNR1A (0.47) | — | |
| SCHEMBL10411797 | 0.82 | CYSLTR1 (0.49) | — | |
| SCHEMBL10411003 | 0.81 | CYSLTR1 (0.50) | — | |
| SCHEMBL9506820 | 0.80 | MCL1 (0.43) | PTPN11MCL1 | |
| SCHEMBL9303988 | 0.80 | MCL1 (0.57) | PTPN11MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | disclosed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | disclosed |