Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3008191 | 0.77 | — | — | |
| SCHEMBL31708644 | 0.76 | SCN4A (0.43) | SCN4AALDH1A1KMT2ABCHEACHE | |
| SCHEMBL11557198 | 0.75 | — | — | |
| SCHEMBL6685826 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL11557202 | 0.75 | NOS1 (0.53) | NOS1PLAUELANEF2KLKB1 | |
| SCHEMBL31589216 | 0.74 | SCN4A (0.46) | SCN4AALDH1A1KMT2ABCHEACHE | |
| SCHEMBL2181609 | 0.73 | SCN4A (0.62) | SCN4AL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL12128384 | 0.72 | PLAU (0.51) | NOS1PLAUELANEF2KLKB1 | |
| SCHEMBL9507822 | 0.72 | NOS1 (0.50) | NOS1SCN4APLAUELANEF2 | |
| SCHEMBL29296509 | 0.72 | NOS1 (0.50) | NOS1PLAUELANEF2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653127-B2 | Bicyclic pyrazolo-heterocycles | CARA THERAPEUTICS, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-8211926-B2 | Bicyclic pyrazolo-heterocycles | CARA THERAPEUTICS, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-20110275609-A1 | BICYCLIC PYRAZOLO-HETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110144121-A1 | BICYCLIC PYRAZOLO-HETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| EP-0547055-A1 | AGENTS FOR INCREASING BIOMASS PRODUCTION | SKW STICKSTOFFWERKE PIESTERITZ GmbH (DE) | 1993-06-23 | — | — | EP | disclosed |
| WO-1991018509-A1 | AGENTS FOR INCREASING BIOMASS PRODUCTION | STICKSTOFFWERKE AG WITTENBERG-PIESTERITZ (DE) | 1991-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144121-A1 | BICYCLIC PYRAZOLO-HETEROCYCLES | CNR1, CNR2, TRPV1 | NOS1 3258/4885SCN4A 1409/4885PLAU 3985/4885 |
| US-20110275609-A1 | BICYCLIC PYRAZOLO-HETEROCYCLES | CNR1, CNR2, HRH4 | NOS1 3757/4885SCN4A 2373/4885PLAU 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.