Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.49 |
| ▸ | PAM | P19021 | 2/20 | 0.47 |
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | PPARD | Q03181 | 5/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9507155 | 1.00 | TSHR (0.57) | TSHRHCAR2PAMDGKALMNA | |
| Maleic Acid SCHEMBL11159534 | 0.95 | TSHR (0.53) | TSHRHCAR2PAMDGKALMNA | |
| Acrylic Acid SCHEMBL28337927 | 0.91 | TSHR (0.59) | TSHRPAMDGKALMNAPPARG | |
| Bicarbonate SCHEMBL3894794 | 0.91 | TSHR (0.62) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL25420469 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL7540354 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL20476 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL10543145 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL18055 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG | |
| SCHEMBL953501 | 0.91 | TSHR (0.67) | TSHRPAMDGKALMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200431-B1 | DEWAXING WAXY HYDROCARBON OILS USING DI-ALKYL FUMARATE-VINYL LAURATE COPOLYMER DEWAXING AIDS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| EP-0200431-A2 | Dewaxing waxy hydrocarbon oils using di-alkyl fumarate-vinyl laurate copolymer dewaxing aids | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |