Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507472 | 1.00 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1AKR1B10AKR1B1ALDH1A1 | |
| SCHEMBL9560089 | 0.89 | RXRA (0.49) | CYSLTR2CYSLTR1AKR1B10AKR1B1ALDH1A1 | |
| SCHEMBL9560090 | 0.89 | RXRA (0.49) | CYSLTR2CYSLTR1AKR1B10AKR1B1ALDH1A1 | |
| SCHEMBL10424229 | 0.88 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1MAPTHDAC1HDAC8 | |
| SCHEMBL10424230 | 0.88 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1MAPTHDAC1HDAC8 | |
| SCHEMBL9481085 | 0.79 | CYSLTR2 (0.52) | CYSLTR2CYSLTR1MAPTHDAC1HDAC8 | |
| SCHEMBL9721103 | 0.78 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1ALDH1A1LMNAMAPT | |
| SCHEMBL9721098 | 0.78 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1ALDH1A1LMNAMAPT | |
| SCHEMBL9493070 | 0.76 | ALDH1A1 (0.51) | ALDH1A1LMNAGAAMAPT | |
| SCHEMBL9493078 | 0.76 | ALDH1A1 (0.51) | ALDH1A1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-4954513-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |