Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510856 | 0.82 | RAB9A (0.44) | RAB9AL3MBTL1CTSBBCHEEGFR | |
| SCHEMBL5345977 | 0.82 | SLC6A4 (0.47) | HTR7SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL5340091 | 0.80 | SLC6A4 (0.50) | HTR7SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL10701574 | 0.79 | SLC6A4 (0.48) | HTR7SLC6A4SLC6A2SLC6A3TSHR | |
| SCHEMBL31172708 | 0.76 | RAB9A (0.46) | SLC6A4RAB9AL3MBTL1CTSBEGFR | |
| SCHEMBL31172667 | 0.76 | TP53 (0.48) | RAB9AL3MBTL1CTSBEGFRALDH1A1 | |
| SCHEMBL31172733 | 0.75 | NR2E3 (0.49) | RAB9AL3MBTL1CTSBEGFRALDH1A1 | |
| SCHEMBL735118 | 0.74 | SLC6A4 (0.68) | HTR7SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL31172632 | 0.74 | RAB9A (0.44) | SLC6A4RAB9AL3MBTL1CTSBEGFR | |
| SCHEMBL31510902 | 0.74 | HTR1A (0.46) | RAB9AL3MBTL1CTSBEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |