Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27955261 | 0.78 | PARP1 (0.54) | ELANEPARP1RPS6KA3MAPTKDM4E | |
| SCHEMBL11207150 | 0.78 | ELANE (0.42) | ELANEDYRK1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL10781415 | 0.76 | ELANE (0.41) | ELANEDYRK1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL20741518 | 0.73 | F7 (0.48) | ELANEPARP1EGFRKMT2AMEN1 | |
| SCHEMBL29361664 | 0.72 | DYRK1A (0.58) | DYRK1AEGFRKMT2AMEN1MAPT | |
| SCHEMBL912750 | 0.72 | ELANE (0.52) | ELANEPARP1KMT2AMEN1KDM4E | |
| SCHEMBL115366 | 0.72 | DYRK1A (0.58) | DYRK1AEGFRKMT2AMEN1MAPT | |
| SCHEMBL29698724 | 0.72 | ELANE (0.52) | ELANEPARP1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL28263323 | 0.71 | DYRK1A (0.56) | DYRK1AEGFRKMT2AMEN1MAPT | |
| SCHEMBL6260526 | 0.70 | ELANE (0.53) | ELANEKMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0317645-B1 | 4H-3,1-BENZOXAZIN-4-ONE COMPOUNDS AND SERINE PROTEASE-INHIBITING MEDICINAL COMPOSITION CONTAINING SAME | TEIJIN LIMITED (JP) | 1993-09-15 | — | — | EP | disclosed |
| EP-0466944-A1 | 4H-3,1-BENZOXAZIN-4-ONE COMPOUND AND ELASTASE INHIBITOR COMPOSITION CONTAINING THE SAME | TEIJIN LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4980287-A | ANTIINFLAMMATORY AGENTS; INHIBITOR OF DEGENERATION AND DESTRUCTION OF TISSUES | TEIJIN LIMITED (JP) | 1990-12-25 | — | — | US | disclosed |
| EP-0317645-A1 | 4H-3,1-BENZOXAZIN-4-ONE COMPOUNDS AND SERINE PROTEASE-INHIBITING MEDICINAL COMPOSITION CONTAINING SAME | TEIJIN LIMITED (JP) | 1989-05-31 | — | — | EP | disclosed |