SCHEMBL115366

SCHEMBL115366

Nc1ccc2ocnc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 3/20 0.58
KMT2A Q03164 4/20 0.47
MEN1 O00255 3/20 0.47
ALDH1A1 P00352 3/20 0.47
GAA P10253 1/20 0.47
NPC1 O15118 6/20 0.43
RAB9A P51151 6/20 0.43
RXFP1 Q9HBX9 2/20 0.43
GFER P55789 1/20 0.43
SMN1; SMN2 Q16637 4/20 0.42
CTNNB1 P35222 2/20 0.42
WNT3A P56704 2/20 0.42
F2 P00734 1/20 0.41
LMNA P02545 1/20 0.41
CHRM2 P08172 1/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
MAOA P21397 1/20 0.41
DRD1 P21728 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29361664 1.00 DYRK1A (0.58) DYRK1AKMT2AMEN1ALDH1A1GAA
Hydrochloric Acid SCHEMBL28263323 0.98 DYRK1A (0.56) DYRK1AKMT2AMEN1ALDH1A1GAA
Trifluoroacetic Acid SCHEMBL29479758 0.83 MEN1 (0.50) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL116288 0.83 DYRK1A (0.58) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL28209001 0.80 NPC1 (0.49) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL28048555 0.77 DYRK1A (0.72) DYRK1AKMT2AMEN1ALDH1A1GAA
Benzo[D]Oxazole SCHEMBL28373722 0.77 NPC1 (0.46) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL24037592 0.75 DYRK1A (0.40) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL31037246 0.75 ALDH1A1 (0.57) DYRK1AKMT2AMEN1ALDH1A1GAA
SCHEMBL11936084 0.74 TRPM5 (0.53) DYRK1AKMT2AMEN1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120136781-A ROR 1-targeted inhibitor and synthesis method and application thereof 北京大学 2025-06-13 CN claimed
CN-118240309-A Flame-retardant anti-slip sole and manufacturing process thereof 浙江红蜻蜓鞋业股份有限公司 2024-06-25 CN claimed
CN-115368255-B Anthraquinone diamine monomer, cyan intrinsic polyimide derived from anthraquinone diamine monomer and preparation method of cyan intrinsic polyimide 上海交通大学 2024-06-25 CN claimed
CN-117534834-A Polymer, preparation method and application thereof, and intrinsic low-temperature curing negative photoresist 上海交通大学 2024-02-09 CN claimed
CN-112384546-B Thermally conductive resin composition 东洋纺株式会社 2024-01-16 CN claimed
CN-116874885-A Polyarylether grafted carbon nano tube containing heterocyclic structure and continuous fiber reinforced thermoplastic resin matrix composite material thereof 大连理工大学 2023-10-13 CN claimed
CN-116836384-A Polymer for black matrix, preparation method and application thereof 上海交通大学 2023-10-03 CN claimed
CN-115197082-B Anthraquinone diamine monomer, magenta intrinsic polyimide derived from anthraquinone diamine monomer and preparation method of magenta intrinsic polyimide 上海交通大学 2023-09-22 CN claimed
CN-115232303-B Polymer for black matrix, preparation method and application thereof 上海交通大学 2023-09-15 CN claimed
CN-111825867-B Low-dielectric modified polyimide film and preparation method thereof 深圳先进电子材料国际创新研究院 2022-11-15 CN claimed
CN-114426537-A 2-methyl-2H-tetrazole compound and medical application thereof 北京英飞智药科技有限公司 2022-05-03 CN claimed
CN-107779975-B The preparation method of the aromatic polyamide fibre of high-performance heterocyclic containing chlorine 哈尔滨工业大学 2019-11-15 CN claimed
CN-106749079-B The amide electrolyte preparation method of diamines containing benzoxazoles and application 哈尔滨工业大学 2019-03-26 CN claimed
CN-208553278-U Filter device of the one kind for the production of -2 (3H) -one of 5- amino -1,3- benzoxazoles 南京华安药业有限公司 2019-03-01 CN claimed
EP-2533053-B1 Method for the determination of the concentration of vitamin B6 in a sample BÜHLMANN LAB AG (CH) 2015-09-09 EP claimed
CN-1583752-A Synthesis of benzoxazole UNIV HARBIN POLYTECHNIC (CN) 2005-02-23 CN claimed
US-5017471-A Reagent for peroxidase detection EPITOPE, INC. (US) 1991-05-21 US claimed
US-3977882-A CARBOCYANINE DYES FUJI PHOTO FILM CO., LTD. (JA) 1976-08-31 US claimed
US-12528827-B2 Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2026-01-20 US disclosed
US-3977882-A CARBOCYANINE DYES FUJI PHOTO FILM CO., LTD. (JA) 1976-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12528827-B2 Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors F2RL3, F2R, PF4 DYRK1A 2346/4885KMT2A 2733/4885MEN1 2007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.