Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6483099 | 0.98 | TDP1 (0.50) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL12463289 | 0.81 | ALOX15 (0.56) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL3682215 | 0.79 | TDP1 (0.54) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL1352508 | 0.79 | TDP1 (0.54) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL9676726 | 0.78 | NPSR1 (0.47) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL356244 | 0.77 | ALOX15 (0.52) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL27848958 | 0.77 | TDP1 (0.52) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL13484170 | 0.77 | TDP1 (0.52) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL1352506 | 0.77 | TDP1 (0.52) | TDP1ALOX15CYP3A4SMN1; SMN2TP53 | |
| SCHEMBL27463746 | 0.76 | CYP3A4 (0.39) | TDP1ALOX15CYP3A4SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204215-B1 | 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | disclosed |
| EP-0204215-A1 | 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines | G.D. Searle & Co. (US) | 1986-12-10 | — | — | EP | disclosed |