Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.50 |
| ▸ | BID | P55957 | 2/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510487 | 0.87 | BID (0.48) | LTB4RLTB4R2BIDBCL2L1MCL1 | |
| SCHEMBL9579671 | 0.84 | MRGPRX4 (0.47) | LTB4R | |
| SCHEMBL9510492 | 0.84 | PRSS1 (0.48) | LTB4R | |
| SCHEMBL9510377 | 0.82 | LTB4R (0.55) | LTB4RLTB4R2PLA2G2D | |
| SCHEMBL9506689 | 0.81 | LTB4R (0.41) | LTB4RBIDBCL2L1MCL1BAK1 | |
| SCHEMBL9507003 | 0.81 | LTB4R (0.49) | LTB4RPLA2G2D | |
| SCHEMBL7777769 | 0.81 | GRM2 (0.54) | LTB4RLTB4R2 | |
| SCHEMBL9508106 | 0.81 | GRM2 (0.54) | LTB4RLTB4R2 | |
| SCHEMBL9506867 | 0.81 | GRM2 (0.54) | LTB4RLTB4R2 | |
| SCHEMBL9325773 | 0.81 | PLA2G2A (0.65) | BIDBCL2L1MCL1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | disclosed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | disclosed |