Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508117 | 1.00 | HDAC1 (0.56) | HDAC1HDAC3SMPD1HDAC6HDAC8 | |
| SCHEMBL20810480 | 0.85 | SMN1; SMN2 (0.55) | SMPD1SMN1; SMN2 | |
| SCHEMBL27557941 | 0.85 | PPARA (0.40) | HDAC1HDAC8SMN1; SMN2 | |
| SCHEMBL20810490 | 0.84 | SMN1; SMN2 (0.52) | HDAC1HDAC3SMN1; SMN2 | |
| SCHEMBL9504789 | 0.83 | STS (0.51) | — | |
| SCHEMBL9504784 | 0.83 | STS (0.51) | — | |
| SCHEMBL9506061 | 0.83 | STS (0.51) | — | |
| SCHEMBL9504363 | 0.83 | TNNC1 (0.51) | HDAC1HDAC3SMPD1HDAC6HDAC8 | |
| SCHEMBL9504799 | 0.83 | TNNC1 (0.51) | HDAC1HDAC3SMPD1HDAC6HDAC8 | |
| SCHEMBL9504807 | 0.83 | TNNC1 (0.51) | HDAC1HDAC3SMPD1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |