Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.72 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 14/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | FPR3 | P25089 | 1/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.72 |
| ▸ | HTR1D | P28221 | 1/20 | 0.72 |
| ▸ | HTR1B | P28222 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | GPR183 | P32249 | 1/20 | 0.72 |
| ▸ | HTR7 | P34969 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044430 | 0.87 | ADRB2 (0.85) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL14017126 | 0.86 | ADRB2 (0.96) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL4454918 | 0.86 | ADRB2 (0.96) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL14030775 | 0.84 | ADRB2 (0.78) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL4868000 | 0.84 | ADRB2 (0.78) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| Salmeterol SCHEMBL29393289 | 0.84 | ADRB2 (1.00) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| Salmeterol SCHEMBL29397921 | 0.84 | ADRB2 (1.00) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| Salmeterol SCHEMBL4767 | 0.84 | ADRB2 (1.00) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| Salmeterol SCHEMBL4452108 | 0.84 | ADRB2 (1.00) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL4450046 | 0.84 | ADRB2 (1.00) | ADRB2ADRB3ADRB1KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322164-B1 | ETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-22 | — | — | EP | claimed |
| EP-0322164-A2 | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | claimed |
| EP-0322164-B1 | ETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-22 | — | — | EP | disclosed |
| EP-0322164-A2 | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |