SCHEMBL950846

SCHEMBL950846

Cc1cc(Cl)cc(C(=O)NN)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.85

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.44
MALT1 Q9UDY8 3/20 0.37
P2RX7 Q99572 1/20 0.37
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
DRD4 P21917 1/20 0.34
F10 P00742 1/20 0.34
GRM4 Q14833 3/20 0.33
LMNA P02545 1/20 0.33
NTRK1 P04629 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
PSD A5PKW4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28867325 0.93 DHODH (0.45) DHODHMALT1MAPTDRD4F10
SCHEMBL29377193 0.92 DHODH (0.44) DHODHMALT1ALDH1A1GRM4NTRK1
Chlorantraniliprole SCHEMBL29551 0.92 DHODH (0.44) DHODHMALT1DRD4F10NTRK1
SCHEMBL15984455 0.92 DHODH (0.44) DHODHMALT1ALDH1A1GRM4NTRK1
Chlorantraniliprole SCHEMBL29363261 0.92 DHODH (0.44) DHODHMALT1DRD4F10NTRK1
SCHEMBL31060097 0.92 DHODH (0.44) DHODHMALT1ALDH1A1GRM4NTRK1
SCHEMBL902720 0.92 DHODH (0.46) DHODHMALT1F10GRM4TRPV1
SCHEMBL14713967 0.91 DHODH (0.43) DHODHMALT1DRD4F10
SCHEMBL12912066 0.91 DHODH (0.44) DHODHMALT1DRD4F10TRPV1
SCHEMBL30473348 0.91 DHODH (0.45) DHODHMALT1LMNANTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109912585-B Pyridine pyrazole-4-formamide compound based on sulfur-containing functional group and preparation method and application thereof 江苏耘农化工有限公司 2021-09-17 CN disclosed
WO-2011085684-A1 O-HETEROCYCLYL FORMANILIDE COMPOUNDS, THEIR SYNTHESIS METHODS AND USE 江苏省农药研究所股份有限公司 (CN) 2011-07-21 WO disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-22 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC1, UQCRC2, Q6ZSR9 DHODH 277/4885MALT1 4850/4885P2RX7 1424/4885
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 DHODH 771/4885MALT1 4856/4885P2RX7 926/4885
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC2, UQCRC1, UQCRB DHODH 558/4885MALT1 4804/4885P2RX7 1192/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT DHODH 284/4885MALT1 4865/4885P2RX7 1292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.