⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19384655 | 0.98 | NOTUM (0.40) | — | |
| Biphenyl SCHEMBL27658278 | 0.89 | PIN1 (0.47) | — | |
| SCHEMBL15195597 | 0.82 | — | — | |
| SCHEMBL19384586 | 0.80 | — | — | |
| SCHEMBL169065 | 0.80 | — | — | |
| SCHEMBL5761874 | 0.78 | NPSR1 (0.48) | — | |
| SCHEMBL1559800 | 0.77 | MAP4K1 (0.38) | — | |
| SCHEMBL15186359 | 0.77 | YTHDC1 (0.42) | — | |
| SCHEMBL16209016 | 0.76 | KDM4E (0.36) | — | |
| SCHEMBL719025 | 0.75 | KDM4E (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE INSTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-12-09 | — | — | US | claimed |
| US-20230212157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2023-07-06 | — | — | US | claimed |
| US-11597723-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2023-03-07 | — | — | US | claimed |
| US-20150158749-A1 | SELECTIVE EXTRACTION OF ANIONS FROM SOLUTION | THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIVERSITY | 2015-06-11 | — | — | US | claimed |
| CN-101302200-B | Preparation of N-piperidine subbase-5-(4-chlorphenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-formamide | SHANGHAI INST PHARM INDUSTRY | 2011-04-20 | — | — | CN | claimed |
| CN-1047775-C | Substituted N-piperidino-pyrazole-3-carboxamide | SANOFI SA (FR) | 1999-12-29 | — | — | CN | claimed |
| CN-1110968-A | Substituted N-piperidino-pyrazole-3-carboxamide | SANOFI SA (FR) | 1995-11-01 | — | — | CN | claimed |
| US-12492193-B2 | Pyrazole derivatives for the treatment of cystic fibrosis | FONDAZIONE INSTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-12-09 | — | — | US | disclosed |
| CN-119039225-A | Purification method of fluorine-containing methyl pyrazole carboxylic ester | 中蓝晨光化工研究设计院有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-118541371-A | Methionine adenosyltransferase 2A inhibitors for the treatment of MTAP deleted cancers | 勤浩医药（苏州）有限公司 | 2024-08-23 | — | — | CN | disclosed |
| EP-4413004-A1 | MACROCYCLIC COMPOUNDS HAVING ENT1 INHIBITING ACTIVITY | iTeos Belgium SA (BE) | 2024-08-14 | — | — | EP | disclosed |
| US-20230391752-A1 | PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AND RELATED USES | CHULALONGKORN UNIVERSITY (TH) | 2023-12-07 | — | — | US | disclosed |
| CN-116547275-A | IL-17A modulators | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| CN-1582278-A | Polymorphous form of rimonabant, process for its preparation and pharmaceutical compositions containing it | SANOFI SYNTHELABO (FR) | 2005-02-16 | — | — | CN | disclosed |
| EP-1444210-A1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2004058702-A2 | 4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058763-A1 | 4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2003040108-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |
| CN-1047775-C | Substituted N-piperidino-pyrazole-3-carboxamide | SANOFI SA (FR) | 1999-12-29 | — | — | CN | disclosed |
| CN-1110968-A | Substituted N-piperidino-pyrazole-3-carboxamide | SANOFI SA (FR) | 1995-11-01 | — | — | CN | disclosed |