SCHEMBL9508737

SCHEMBL9508737

CCOc1ccc(C#Cc2ccc(CC)cc2)c(F)c1F

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.37
ACACB O00763 17/20 0.36
FFAR1 O14842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9509292 0.97 RXRA (0.35) CYP2A6ACACB
SCHEMBL9511350 0.90 ACACB (0.38) CYP2A6ACACB
SCHEMBL16692008 0.90 TACR2 (0.37) ACACB
SCHEMBL9508745 0.89 ACACB (0.38) CYP2A6ACACB
SCHEMBL7910413 0.88 ACACB (0.40) ACACBFFAR1
SCHEMBL9510152 0.88 FFAR1 (0.40) CYP2A6ACACBFFAR1
SCHEMBL9509358 0.88 ACACB (0.37) CYP2A6ACACB
SCHEMBL9509283 0.88 ALDH1A1 (0.37) CYP2A6ACACB
SCHEMBL9508858 0.86 ACACB (0.37) ACACB
SCHEMBL9508805 0.86 ALDH1A1 (0.39) ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP claimed
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed