Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28262419 | 0.81 | ALDH1A1 (0.34) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL4954295 | 0.78 | ALDH1A1 (0.35) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL29956570 | 0.78 | TRIM24 (0.52) | ALDH1A1L3MBTL1ADRB2TRIM24TRIM33 | |
| SCHEMBL10817580 | 0.78 | ALDH1A1 (0.39) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL29108311 | 0.78 | ALDH1A1 (0.53) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL30706494 | 0.78 | TRIM24 (0.52) | ALDH1A1L3MBTL1ADRB2TRIM24TRIM33 | |
| SCHEMBL17221090 | 0.76 | ALDH1A1 (0.41) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL5698590 | 0.74 | CXCR4 (0.33) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL20767516 | 0.74 | KDM4E (0.41) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL20817821 | 0.74 | CXCR4 (0.33) | CXCR4ALDH1A1L3MBTL1TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292797-B1 | PROCESS FOR PREPARING PARTICLES OF OLEFIN-MALEIC ANHYDRIDE COPOLYMER | Kao Corporation (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-4795792-A | CATIONIC DISPERSANT | KAO CORPORATION (JP) | 1989-01-03 | — | — | US | disclosed |
| EP-0292797-A2 | Process for preparing particles of olefin-maleic anhydride copolymer | Kao Corporation (JP) | 1988-11-30 | — | — | EP | disclosed |