Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.33 |
| ▸ | FABP6 | P51161 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767501 | 0.85 | PARP1 (0.45) | KDM4ETRIM24TRIM33MEN1KMT2A | |
| Bicarbonate SCHEMBL8962456 | 0.85 | KDM4E (0.35) | KDM4EPAX8ALDH1A1CXCR4MEN1 | |
| SCHEMBL28183445 | 0.84 | KDM4E (0.42) | KDM4EMETCALM1PAX8TAAR1 | |
| SCHEMBL17595558 | 0.84 | TRIM24 (0.48) | KDM4EMETCALM1PAX8TAAR1 | |
| SCHEMBL11633202 | 0.82 | KDM4E (0.41) | KDM4EMETCALM1PAX8TAAR1 | |
| SCHEMBL7640865 | 0.77 | CALM1 (0.37) | CALM1TAAR1ALDH1A1LTB4RSMO | |
| SCHEMBL7640856 | 0.76 | CALM1 (0.39) | KDM4ECALM1TAAR1ALDH1A1HSD17B10 | |
| SCHEMBL38230 | 0.76 | MET (0.40) | KDM4EMETCALM1PAX8TAAR1 | |
| SCHEMBL29108311 | 0.76 | ALDH1A1 (0.53) | KDM4EALDH1A1HSD17B10TRIM24TRIM33 | |
| SCHEMBL10817580 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1HSD17B10TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257027-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2025-08-14 | — | — | US | disclosed |
| US-12269798-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2025-04-08 | — | — | US | disclosed |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2021-09-30 | — | — | US | disclosed |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2021-09-30 | — | — | US | disclosed |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2021-06-08 | — | — | US | disclosed |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2020-06-18 | — | — | US | disclosed |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2020-06-18 | — | — | US | disclosed |
| WO-2019040792-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019040792-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2019-02-28 | — | — | WO | disclosed |
| CN-102154654-A | Acid washing corrosion inhibitor | ZHEJIANG FURWARD ANIMAL MEDICINE & HEALTH PRODUCTS CO LTD | 2011-08-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12269798-B2 | Second generation GRP94-selective inhibitors | HSP90B1, HSP90AB2P, HSPE1 | KDM4E 4511/4885MET 716/4885CALM1 2173/4885 |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | KDM4E 4511/4885MET 716/4885CALM1 2173/4885 |
| US-20250257027-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | KDM4E 4511/4885MET 737/4885CALM1 2110/4885 |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | HSP90B1, HSP90AB2P, HSPE1 | KDM4E 4511/4885MET 737/4885CALM1 2110/4885 |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | KDM4E 4511/4885MET 737/4885CALM1 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.