Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.44 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.44 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14465565 | 0.98 | MAOA (0.53) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL6866606 | 0.82 | MAOA (0.57) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL6866612 | 0.82 | MAOA (0.57) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL399162 | 0.78 | SMN1; SMN2 (0.56) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL26780011 | 0.78 | MAOA (0.53) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL12614725 | 0.78 | MAOA (0.53) | MAOAMAOBSMN1; SMN2CHRM2KDM4E | |
| Ethyne SCHEMBL1922812 | 0.76 | SMN1; SMN2 (0.53) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL13373201 | 0.76 | MAOA (0.50) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL5411231 | 0.76 | CHRM2 (0.56) | MAOAMAOBSMN1; SMN2CHRM2NPC1 | |
| SCHEMBL15066769 | 0.76 | SMN1; SMN2 (0.53) | MAOAMAOBSMN1; SMN2CHRM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292797-B1 | PROCESS FOR PREPARING PARTICLES OF OLEFIN-MALEIC ANHYDRIDE COPOLYMER | Kao Corporation (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-4795792-A | CATIONIC DISPERSANT | KAO CORPORATION (JP) | 1989-01-03 | — | — | US | disclosed |
| EP-0292797-A2 | Process for preparing particles of olefin-maleic anhydride copolymer | Kao Corporation (JP) | 1988-11-30 | — | — | EP | disclosed |