SCHEMBL9508798

SCHEMBL9508798

CCCCCCc1ccc(C#Cc2ccc(OCOC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
LMNA P02545 2/20 0.50
CYP3A4 P08684 2/20 0.50
MEN1 O00255 1/20 0.50
USP2 O75604 1/20 0.50
MAPK1 P28482 1/20 0.50
CASP1 P29466 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
SLCO1B3 Q9NPD5 1/20 0.50
SLCO1B1 Q9Y6L6 1/20 0.50
HSD17B10 Q99714 2/20 0.49
TSHR P16473 1/20 0.49
THRB P10828 2/20 0.47
THRA P10827 1/20 0.47
ESR1 P03372 2/20 0.45
ADRA2A P08913 2/20 0.45
ADORA3 P0DMS8 2/20 0.45
TACR2 P21452 2/20 0.45
SLC6A2 P23975 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508794 1.00 ALDH1A1 (0.50) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9510203 0.98 ALDH1A1 (0.48) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9512255 0.94 ACACB (0.45) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL10405439 0.92 ALDH1A1 (0.56) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9015403 0.92 ALDH1A1 (0.56) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9512388 0.88 ALDH1A1 (0.54) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL10512628 0.88 ALDH1A1 (0.54) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9511398 0.88 ALDH1A1 (0.54) ALDH1A1LMNACYP3A4MEN1USP2
SCHEMBL9512506 0.87 ACACB (0.47) ALDH1A1THRBACACB
SCHEMBL9509398 0.87 ALDH1A1 (0.59) ALDH1A1LMNACYP3A4MEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed