SCHEMBL9508877

SCHEMBL9508877

O=C(c1cc2c(cc1Cl)Oc1cc(Cl)c(C(=O)C(F)(F)F)cc1S2)C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
FLT1 P17948 1/20 0.33
AHR P35869 1/20 0.33
MAPT P10636 1/20 0.32
NPC1 O15118 2/20 0.32
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MAPK1 P28482 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508195 0.83 AHR (0.38) KDM4EFLT1AHRMAPTMAPK1
SCHEMBL9508904 0.80 AHR (0.38) KDM4EFLT1AHRMAPT
SCHEMBL9511385 0.70 AHR (0.60) FLT1AHR
SCHEMBL9479377 0.67 SMN1; SMN2 (0.35) PTGS2
SCHEMBL9510151 0.67 AHR (0.44) FLT1AHR
SCHEMBL9937692 0.65 ALDH1A1 (0.59) RAB9AKDM4EHPGDFLT1MAPT
SCHEMBL5860599 0.65 AHR (0.46) HPGDFLT1AHR
SCHEMBL10580560 0.65 TSHR (0.59) RAB9AKDM4EMEN1HPGDKMT2A
SCHEMBL9510076 0.65 AHR (0.37) FLT1AHR
SCHEMBL10652247 0.64 AHR (0.44) MEN1KMT2AFLT1AHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed