SCHEMBL9509488

SCHEMBL9509488

Cc1cc(N(C)C)ccc1-c1[c]ccc(N(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.39
ALDH1A1 P00352 3/20 0.36
TSHR P16473 2/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TERT O14746 1/20 0.33
APP P05067 1/20 0.33
CRHR1 P34998 1/20 0.33
APAF1 O14727 1/20 0.33
PDK2 Q15119 1/20 0.30
PSMB5 P28074 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6780746 0.84 SNCA (0.37) MAPTALDH1A1TSHRAPPCRHR1
SCHEMBL9507485 0.84 SNCA (0.37) MAPTALDH1A1TSHRHSD17B10APP
SCHEMBL10888098 0.84 CYP1A2 (0.38) MAPTALDH1A1TSHRHSD17B10PDK2
SCHEMBL10465072 0.82 ALDH1A1 (0.37) MAPTALDH1A1TSHRALOX15HSD17B10
SCHEMBL10895812 0.81 ALDH1A1 (0.35) MAPTALDH1A1TSHRALOX15HSD17B10
SCHEMBL10897063 0.81 ALDH1A1 (0.35) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL10892285 0.78 ALDH1A1 (0.34) MAPTALDH1A1TSHRALOX15HSD17B10
SCHEMBL13990194 0.78 ALDH1A1 (0.50) MAPTALDH1A1TSHRALOX15HSD17B10
SCHEMBL30966777 0.78 ALDH1A1 (0.50) MAPTALDH1A1TSHRALOX15HSD17B10
SCHEMBL8064164 0.76 ALDH1A1 (0.44) MAPTALDH1A1TSHRALOX15HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396828-B1 UNSYMMETRICAL SQUARAINE COMPOSITIONS AND PHOTOCONDUCTIVE IMAGING MEMBERS USING SUCH COMPOSITIONS XEROX CORPORATION (US) 1993-08-11 EP disclosed
US-5030537-A Photoconductive unsymmetrical squaraine compositions XEROX CORPORATION (US) 1991-07-09 US disclosed
EP-0396828-A1 Unsymmetrical squaraine compositions and photoconductive imaging members using such compositions XEROX CORPORATION (US) 1990-11-14 EP disclosed
US-4922018-A Photoconductive imaging members with unsymmetrical squaraine compositions XEROX CORPORATION (US) 1990-05-01 US disclosed
US-4886722-A Photoconductive imaging members with unsymmetrical squaraine compositions XEROX CORPORATION (US) 1989-12-12 US disclosed