SCHEMBL9510018

SCHEMBL9510018

Cc1cc2c(c(Cl)c1Cl)Sc1c(cc(C)c(Cl)c1Cl)O2

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.34
CHRM1 P11229 1/20 0.34
ALOX15 P16050 1/20 0.34
MAOA P21397 1/20 0.34
TBXA2R P21731 1/20 0.34
ADRA1A P35348 1/20 0.34
HTR2B P41595 1/20 0.34
FLT1 P17948 1/20 0.33
AHR P35869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508965 0.81 AHR (0.36) AHR
SCHEMBL9511341 0.77 AHR (0.50) CYP3A4FLT1AHR
SCHEMBL6308926 0.77 AHR (0.42) FLT1AHR
SCHEMBL9508939 0.75 TSHR (0.39)
SCHEMBL9511229 0.68 AHR (0.38) FLT1AHR
SCHEMBL9509978 0.68 AHR (0.38) FLT1AHR
SCHEMBL9508070 0.66 AHR (0.40) FLT1AHR
SCHEMBL9510067 0.66 AHR (0.35) CYP3A4FLT1AHR
SCHEMBL15845264 0.64
SCHEMBL10292488 0.64 AHR (0.44) CYP3A4FLT1AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed