SCHEMBL9510033

SCHEMBL9510033

COC(=O)c1cc(Cl)c2c(c1Cl)Sc1c(cc(Cl)c(C(=O)OC)c1Cl)O2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.37
ABL1 P00519 1/20 0.33
NQO2 P16083 3/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 2/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
HSD17B10 Q99714 2/20 0.32
CYP3A4 P08684 2/20 0.32
MAPT P10636 2/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
SLCO1B3 Q9NPD5 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
SLCO1B1 Q9Y6L6 1/20 0.32
HTT P42858 1/20 0.31
NR4A2 P43354 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9507662 0.86 GAA (0.36) GAAABL1NQO2ALDH1A1KDM4E
SCHEMBL522450 0.73 GAA (0.49) GAAABL1NQO2KDM4EMEN1
SCHEMBL9510067 0.70 AHR (0.35) MEN1KMT2ACYP3A4HPGD
SCHEMBL1706798 0.67 GAA (0.53) GAAABL1NQO2ALDH1A1KDM4E
SCHEMBL11697659 0.66 NR4A2 (0.41) GAAABL1NQO2KDM4EMEN1
SCHEMBL8331805 0.64 GAA (0.51) GAAABL1NQO2KDM4EMEN1
SCHEMBL31147102 0.64 GAA (0.51) GAAABL1NQO2ALDH1A1KDM4E
SCHEMBL9511428 0.63 GAA (0.36) GAAALDH1A1KDM4EMEN1KMT2A
SCHEMBL1953848 0.63 GAA (0.58) GAAABL1ALDH1A1KDM4EMEN1
SCHEMBL70011 0.63 GAA (0.58) GAAABL1ALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed