SCHEMBL9507662

SCHEMBL9507662

COC(=O)c1c(Cl)cc2c(c1Cl)Sc1c(cc(Cl)c(C(=O)OC)c1Cl)O2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.36
ALDH1A1 P00352 4/20 0.35
NR4A2 P43354 1/20 0.35
NOTUM Q6P988 1/20 0.35
CYP3A4 P08684 3/20 0.34
MAPT P10636 3/20 0.34
HSD17B10 Q99714 2/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
HPGD P15428 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MAPK1 P28482 1/20 0.34
SLCO1B3 Q9NPD5 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
SLCO1B1 Q9Y6L6 1/20 0.34
ABL1 P00519 1/20 0.34
POLB P06746 1/20 0.34
CA12 O43570 3/20 0.33
CA9 Q16790 3/20 0.33
CA2 P00918 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9510033 0.86 GAA (0.37) GAAALDH1A1NR4A2CYP3A4MAPT
SCHEMBL9510067 0.82 AHR (0.35) CYP3A4MEN1KMT2AHPGDFLT1
SCHEMBL9511428 0.75 GAA (0.36) GAAALDH1A1MAPTHSD17B10MEN1
SCHEMBL9508182 0.74 ALDH1A1 (0.38) GAAALDH1A1MAPTHSD17B10MEN1
SCHEMBL9511203 0.73 AHR (0.34) FLT1AHR
SCHEMBL9511341 0.69 AHR (0.50) ALDH1A1CYP3A4HSD17B10HPGDMAPK1
SCHEMBL522450 0.69 GAA (0.49) GAANR4A2CYP3A4HSD17B10MEN1
SCHEMBL8513199 0.69 CA12 (0.42) GAAALDH1A1NR4A2CYP3A4HSD17B10
SCHEMBL6308926 0.69 AHR (0.42) FLT1AHR
SCHEMBL5542753 0.68 KMT2A (0.53) GAAALDH1A1CYP3A4MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed