SCHEMBL9510078

SCHEMBL9510078

COC(=O)c1cc2c(cc1Cl)Oc1cc(Cl)ccc1S2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.48
ALDH1A1 P00352 4/20 0.42
CA12 O43570 2/20 0.41
CA9 Q16790 2/20 0.41
NR4A2 P43354 2/20 0.40
LMNA P02545 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
KDM4E B2RXH2 4/20 0.39
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CA2 P00918 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
AHR P35869 1/20 0.38
MRGPRX4 Q96LA9 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9511441 0.76 GAA (0.45) ABL1ALDH1A1CA12CA9NR4A2
SCHEMBL9511327 0.76 GAA (0.45) ABL1ALDH1A1CA12CA9NR4A2
SCHEMBL9508195 0.75 AHR (0.38) ALDH1A1MAPTKDM4ESMN1; SMN2AHR
SCHEMBL9508904 0.72 AHR (0.38) MAPTKDM4EAHRFLT1
SCHEMBL4363906 0.71 ABL1 (0.62) ABL1ALDH1A1NR4A2LMNAMEN1
SCHEMBL608814 0.71 ABL1 (0.68) ABL1ALDH1A1NR4A2MEN1MAPT
SCHEMBL11300844 0.70 ABL1 (0.61) ABL1ALDH1A1NR4A2LMNAMEN1
SCHEMBL70011 0.69 GAA (0.58) ABL1ALDH1A1CA12CA9NR4A2
SCHEMBL16724062 0.69 SLC6A4 (0.43) ABL1ALDH1A1NR4A2LMNAMEN1
SCHEMBL9699563 0.68 AHR (0.43) KDM4EAHRFLT1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed