Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946588 | 0.86 | KDM4E (0.47) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL7703559 | 0.83 | KDM4E (0.49) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL13651216 | 0.82 | KDM4E (0.48) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL824999 | 0.82 | KDM4E (0.44) | KDM4EPOLBPDE4DL3MBTL1ALOX12 | |
| SCHEMBL27321987 | 0.79 | KDM4E (0.42) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL1018503 | 0.79 | KDM4E (0.46) | KDM4EPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL948640 | 0.79 | SMN1; SMN2 (0.59) | KDM4EPOLBTP53ALOX12MEN1 | |
| SCHEMBL951258 | 0.78 | KDM4E (0.41) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL719025 | 0.78 | KDM4E (0.49) | KDM4EPOLBPDE4DL3MBTL1MEN1 | |
| SCHEMBL3376695 | 0.76 | KDM4E (0.51) | KDM4EPOLBPDE4DL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451450-B1 | Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections | PASTEUR INSTITUT (FR) | 2014-07-02 | — | — | EP | disclosed |
| EP-2451450-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | Institut Pasteur (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011004323-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | INSTITUT PASTEUR (FR) | 2011-01-13 | — | — | WO | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |