Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824999 | 0.89 | KDM4E (0.44) | KDM4EPOLBLMNAPDE4DL3MBTL1 | |
| SCHEMBL946588 | 0.84 | KDM4E (0.47) | KDM4EPOLBPDE4DL3MBTL1ALDH1A1 | |
| SCHEMBL8584565 | 0.83 | HCAR2 (0.40) | HCAR3HCAR2ALDH1A1PPARGPPARA | |
| SCHEMBL948543 | 0.83 | HCAR2 (0.46) | HCAR3HCAR2PPARGPPARA | |
| SCHEMBL11365602 | 0.81 | HCAR2 (0.48) | HCAR3HCAR2PPARGPPARA | |
| SCHEMBL7703559 | 0.81 | KDM4E (0.49) | KDM4EPOLBPDE4DL3MBTL1ALDH1A1 | |
| SCHEMBL13651216 | 0.80 | KDM4E (0.48) | KDM4EPOLBLMNAPDE4DL3MBTL1 | |
| SCHEMBL951011 | 0.78 | KDM4E (0.43) | KDM4EPOLBPDE4DL3MBTL1MAPT | |
| SCHEMBL4878445 | 0.78 | HCAR2 (0.47) | KDM4ELMNAL3MBTL1HCAR3HCAR2 | |
| SCHEMBL27321987 | 0.77 | KDM4E (0.42) | KDM4EPOLBPDE4DL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451450-B1 | Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections | PASTEUR INSTITUT (FR) | 2014-07-02 | — | — | EP | disclosed |
| EP-2451450-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | Institut Pasteur (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011004323-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | INSTITUT PASTEUR (FR) | 2011-01-13 | — | — | WO | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |