Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946588 | 0.89 | KDM4E (0.47) | KDM4EPOLBPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL13651216 | 0.88 | KDM4E (0.48) | KDM4EPOLBPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL824999 | 0.85 | KDM4E (0.44) | KDM4EPOLBPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL951011 | 0.83 | KDM4E (0.43) | KDM4EPOLBPDE4DCYP1A2L3MBTL1 | |
| SCHEMBL27321987 | 0.82 | KDM4E (0.42) | KDM4EPOLBPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL951258 | 0.81 | KDM4E (0.41) | KDM4EPOLBPDE4DALDH1A1L3MBTL1 | |
| SCHEMBL719025 | 0.80 | KDM4E (0.49) | KDM4EPOLBPDE4DCYP1A2ALDH1A1 | |
| SCHEMBL3376695 | 0.79 | KDM4E (0.51) | KDM4EPOLBPDE4DALDH1A1L3MBTL1 | |
| SCHEMBL948640 | 0.79 | SMN1; SMN2 (0.59) | KDM4EPOLBCYP1A2ALDH1A1KMT2A | |
| SCHEMBL8816833 | 0.78 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |