Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27200193 | 0.80 | HDAC8 (0.41) | HDAC8HDAC1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL9972448 | 0.79 | HDAC8 (0.43) | HTTHDAC8HDAC1PDE4BTHRA | |
| SCHEMBL27200200 | 0.77 | CTNNB1 (0.43) | HTTHDAC8HDAC1PDE4BPOLB | |
| SCHEMBL24783614 | 0.76 | PLA2G2A (0.39) | HDAC8HDAC1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL9508047 | 0.76 | PLA2G2A (0.39) | HDAC8HDAC1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL9972449 | 0.74 | HTT (0.44) | HTTLMNAALDH1A1 | |
| SCHEMBL8711802 | 0.73 | PLAU (0.41) | HTTHDAC8HDAC1MAPK1SMN1; SMN2 | |
| SCHEMBL23534095 | 0.73 | POLB (0.41) | HDAC8HDAC1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL29767827 | 0.73 | POLB (0.41) | HDAC8HDAC1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1441802 | 0.73 | KMT2A (0.49) | HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | disclosed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-4937373-A | Substituted naphthalene carboxylic acids | HOFFMANN-LA ROCHE INC. (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | disclosed |