Meprednisone

Meprednisone

SCHEMBL9512

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Meprednisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 known ✓ P04150 6/20 0.70
HSD17B10 Q99714 6/20 0.70
HIF1A Q16665 6/20 0.70
PGR P06401 5/20 0.70
KMT2A Q03164 3/20 0.70
LMNA P02545 3/20 0.70
MEN1 O00255 2/20 0.70
ALDH1A1 P00352 1/20 0.70
SLC29A1 Q99808 1/20 0.70
TDP1 Q9NUW8 1/20 0.70
FNTA P49354 1/20 0.57
FNTB P49356 1/20 0.57
NFKB1 P19838 4/20 0.55
NFKB2 Q00653 2/20 0.55
RELA Q04206 2/20 0.55
KCNH2 Q12809 1/20 0.55
CYP3A4 P08684 6/20 0.54
AR P10275 3/20 0.54
TSHR P16473 2/20 0.54
CYP2D6 P10635 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Meprednisone SCHEMBL20856991 1.00 HSD17B10 (0.70) HSD17B10NR3C1HIF1APGRKMT2A
Meprednisone SCHEMBL5483442 1.00 HSD17B10 (0.70) HSD17B10NR3C1HIF1APGRKMT2A
Meprednisone SCHEMBL19327148 1.00 HSD17B10 (0.70) HSD17B10NR3C1HIF1APGRKMT2A
Meprednisone SCHEMBL11846862 1.00 HSD17B10 (0.70) HSD17B10NR3C1HIF1APGRKMT2A
Meprednisone SCHEMBL16759699 0.93 HSD17B10 (0.83) HSD17B10NR3C1HIF1APGRKMT2A
SCHEMBL25932838 0.91 NR3C1 (0.60) HSD17B10NR3C1HIF1APGRKMT2A
SCHEMBL7611011 0.89 FNTA (0.60) HSD17B10NR3C1HIF1APGRKMT2A
SCHEMBL11038018 0.88 KMT2A (0.72) HSD17B10NR3C1HIF1APGRKMT2A
SCHEMBL11038901 0.88 KMT2A (0.72) HSD17B10NR3C1HIF1APGRKMT2A
SCHEMBL11038015 0.88 KMT2A (0.72) HSD17B10NR3C1HIF1APGRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11546 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
US-20260103492-A1 CYCLOSPORINE COMPOSITIONS AND METHODS OF USE BACAINN BIOTHERAPEUTICS, LTD. (KY) 2026-04-16 US claimed
EP-4301343-B1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC BIOPHARMACEUTICALS INC (US) 2025-11-19 EP claimed
US-12421281-B2 Cyclosporine compositions and methods of use BACAINN BIOTHERAPEUTICS, LTD. (KY) 2025-09-23 US claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
WO-2025123147-A1 TOLERIZING IMMUNOMODULATORY COMBINATION INTEGRATED NANOTHERAPEUTICS INC. (CA) 2025-06-19 WO claimed
EP-4567037-A1 USE OF PYRROLOPYRIMIDINE COMPOUND IN TREATMENT OF ACUTE GRAFT VERSUS HOST DISEASE Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2025-06-11 EP claimed
US-20250179121-A1 CYCLOSPORINE COMPOSITIONS AND METHODS OF USE BACAINN BIOTHERAPEUTICS, LTD. (KY) 2025-06-05 US claimed
US-4540564-A DIHYDROPYRIDINE AND/OR PYRIDINIUM SALT REDOX CARRIER UNIVERSITY OF FLORIDA (US) 1985-09-10 US claimed
US-4478818-A Ocular preparation housing steroid in two different therapeutic forms ALZA CORPORATION (US) 1984-10-23 US claimed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 EP claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed
US-4376767-A ANTIBIOTICS AND PHARMACEUTICALS MERCK & CO., INC. (US) 1983-03-15 US claimed
EP-0055870-A1 Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same MERCK & CO. INC. (US) 1982-07-14 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4312865-A Medication having penetration through cutaneous surfaces into articular and muscular areas SZUCS MURRILL M 1982-01-26 US claimed
US-4221787-A Esteramide prodrugs of anti-inflammatory corticosteroids INTERX RESEARCH CORPORATION (US) 1980-09-09 US claimed
US-4041055-A SULFENYLATION, MICHAEL ADDITION, REACTION WITH THIOPHILE, HYDROLYSIS THE UPJOHN COMPANY (US) 1977-08-09 US claimed