SCHEMBL95120

SCHEMBL95120

CC(=O)Nc1c[c]c(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.50
HTT P42858 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
KMT2A Q03164 5/20 0.48
ALDH1A1 P00352 4/20 0.48
MAPT P10636 4/20 0.48
MEN1 O00255 3/20 0.48
TDP1 Q9NUW8 1/20 0.48
CA12 O43570 1/20 0.48
BRD4 O60885 1/20 0.48
NR1I2 O75469 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
MB P02144 1/20 0.48
CYP1A1 P04798 1/20 0.48
CA3 P07451 1/20 0.48
CYP3A4 P08684 1/20 0.48
RARG P13631 1/20 0.48
TSHR P16473 1/20 0.48
ALOX5AP P20292 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19304816 0.84 RXFP1 (0.51) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL10800714 0.80 TSHR (0.61) CA12CA1CA2TSHRCA9
SCHEMBL10344607 0.80 CYP3A4 (0.56) SMN1; SMN2HTTKMT2AALDH1A1MAPT
SCHEMBL973371 0.78 KMT2A (0.55) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL1740872 0.78 TDP1 (0.55) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL3064656 0.77 SMN1; SMN2 (0.50) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL2683899 0.77 SMN1; SMN2 (0.50) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL27544478 0.77 SMN1; SMN2 (0.50) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL10344809 0.76 L3MBTL1 (0.52) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1
SCHEMBL10344645 0.75 NAMPT (0.53) SMN1; SMN2HTTL3MBTL1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2356103-B1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS TAKEDA GMBH (DE) 2015-08-26 EP claimed
US-8609848-B2 Pyrazolone-derivatives and their use as PDE-4 inhibitors TAKEDA GMBH (DE) 2013-12-17 US claimed
CN-102369194-A Novel pyrazolone derivatives and their use as PD4 inhibitors NYCOMED GMBH 2012-03-07 CN claimed
US-20110218201-A1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS NYCOMED GMBH (DE) 2011-09-08 US claimed
EP-2356103-A1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS Nycomed GmbH (DE) 2011-08-17 EP claimed
WO-2010055083-A1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS NYCOMED GMBH (DE) 2010-05-20 WO claimed
US-20230190730-A1 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT JAPAN TOBACCO INC. (JP) 2023-06-22 US disclosed
US-20200101061-A1 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT JAPAN TOBACCO INC. (JP) 2020-04-02 US disclosed
EP-3406596-A1 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR Japan Tobacco Inc. (JP) 2018-11-28 EP disclosed
US-20180265454-A1 Method for Producing 4-Oxoquinoline Compound JAPAN TOBACCO INC. (JP) 2018-09-20 US disclosed
US-9340522-B2 Pyrazolone-derivatives and their use as PDE-4 inhibitors TAKEDA GMBH (DE) 2016-05-17 US disclosed
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND JAPAN TOBACCO INC (JP) 2015-10-22 US disclosed
EP-2356103-B1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS TAKEDA GMBH (DE) 2015-08-26 EP disclosed
US-20050239819-A1 4-Oxoquinoline compounds and utilization thereof as hiv integrase inhibitors SHIONOGI & CO., LTD. (JP) 2005-10-27 US disclosed
EP-1564210-A1 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS JAPAN TOBACCO INC. (JP) 2005-08-17 EP disclosed
US-5972586-A SUITABLE FOR PRODUCTION OF A COLOR FILTER WHICH COMPRISES A POLYMER COUPLER COMPRISING AT LEAST A YELLOW COUPLER MONOMER AND A CYAN COUPLER MONOMER FUJI PHOTO FILM CO., LTD. (JP) 1999-10-26 US disclosed
US-5800953-A Method for producing color filter using a silver halide color photosensitive material FUJI PHOTO FILM CO., LTD. (JP) 1998-09-01 US disclosed
EP-0192111-B1 ISO-UREAS, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS HERBICIDES BASF Aktiengesellschaft (DE) 1990-05-16 EP disclosed
US-4692187-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1987-09-08 US disclosed
EP-0192111-A1 Iso-ureas, processes for their production and their use as herbicides BASF Aktiengesellschaft (DE) 1986-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150299104-A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND IMPDH1, IMPDH2, CDK20 SMN1; SMN2 3942/4885HTT 4346/4885L3MBTL1 1563/4885
US-20200101061-A1 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT IMPDH1, CDKL4, IMPDH2 SMN1; SMN2 2764/4885HTT 4067/4885L3MBTL1 1404/4885
US-20230190730-A1 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT IMPDH1, IMPDH2, DNTT SMN1; SMN2 2897/4885HTT 3768/4885L3MBTL1 1478/4885
US-20180265454-A1 Method for Producing 4-Oxoquinoline Compound IMPDH1, IMPDH2, CDK20 SMN1; SMN2 3942/4885HTT 4346/4885L3MBTL1 1563/4885
US-20050239819-A1 4-Oxoquinoline compounds and utilization thereof as hiv integrase inhibitors IMPDH1, IMPDH2, TYMP SMN1; SMN2 3133/4885HTT 4202/4885L3MBTL1 1132/4885
US-20110218201-A1 NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS PDE4A, PDE3B, PDE3A SMN1; SMN2 3764/4885HTT 4774/4885L3MBTL1 4809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.