Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512111 | 1.00 | ALDH1A1 (0.44) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510511 | 0.85 | HPGD (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510602 | 0.85 | HPGD (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510513 | 0.85 | HPGD (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9512293 | 0.83 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9512266 | 0.83 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9512280 | 0.83 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510853 | 0.80 | TSHR (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510864 | 0.80 | TSHR (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9510890 | 0.76 | TSHR (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569409-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012959-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-08-06 | — | — | WO | disclosed |