Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 6/20 | 0.41 |
| ▸ | RXRB | P28702 | 5/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186210 | 0.83 | HRH3 (0.47) | KDM4CMEN1KMT2AS1PR5DRD2 | |
| SCHEMBL8188555 | 0.83 | HRH3 (0.47) | KDM4CMEN1KMT2AL3MBTL1S1PR5 | |
| SCHEMBL27248291 | 0.81 | BCL2L1 (0.39) | RXRARXRBRXRGMRGPRX4DRD2 | |
| SCHEMBL9719997 | 0.80 | RXRA (0.55) | RXRARXRBRXRGMRGPRX4HTR7 | |
| SCHEMBL1345450 | 0.77 | KDM4C (0.49) | KDM4CMEN1KMT2AL3MBTL1HTR7 | |
| SCHEMBL6542294 | 0.77 | S1PR5 (0.56) | RXRARXRBRXRGMRGPRX4HTR7 | |
| SCHEMBL12510434 | 0.76 | MEN1 (0.49) | KDM4CMEN1KMT2AL3MBTL1HTR1D | |
| SCHEMBL31091152 | 0.76 | KDM4C (0.46) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL871773 | 0.76 | KMT2A (0.55) | KDM4CMEN1KMT2AL3MBTL1 | |
| SCHEMBL17675580 | 0.76 | L3MBTL1 (0.45) | KDM4CMEN1KMT2AL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |