Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14266803 | 0.91 | KDM4E (0.31) | MEN1KMT2AKDM4EUSP2PTGER4 | |
| SCHEMBL357128 | 0.89 | HDAC1 (0.41) | SMN1; SMN2MAPTCNR2 | |
| SCHEMBL1415560 | 0.88 | TERT (0.32) | MEN1KMT2AAPEX1MAPTALDH1A1 | |
| SCHEMBL4581975 | 0.87 | PTGDR2 (0.38) | MEN1KMT2AKDM4EUSP2PTGER4 | |
| SCHEMBL1401219 | 0.83 | FABP4 (0.45) | KDM4EPTGER4APEX1HPGDPSEN1 | |
| SCHEMBL14266801 | 0.80 | — | — | |
| SCHEMBL13036113 | 0.80 | SIRT2 (0.35) | MEN1KMT2AKDM4EUSP2PTGER4 | |
| SCHEMBL354525 | 0.78 | HSD17B10 (0.40) | SMN1; SMN2CNR2ALDH1A1LMNA | |
| SCHEMBL353790 | 0.76 | HDAC1 (0.51) | SMN1; SMN2MAPT | |
| SCHEMBL1416000 | 0.76 | PSEN1 (0.38) | MEN1KMT2AKDM4EPARGSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1649283-B1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LTD (GB) | 2014-06-18 | — | — | EP | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-8334387-B2 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2012-12-18 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2011-01-20 | — | — | US | disclosed |
| US-7829714-B2 | Method for measuring aromatase activity | GE HEALTHCARE LIMITED (GB) | 2010-11-09 | — | — | US | disclosed |
| US-20100184098-A1 | METHODS FOR MEASURING ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2010-07-22 | — | — | US | disclosed |
| US-20100184098-A1 | METHODS FOR MEASURING ENZYME ACTIVITY | GE HEALTHCARE UK LIMITED (GB) | 2010-07-22 | — | — | US | disclosed |
| US-7727739-B2 | Methods for measuring enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2010-06-01 | — | — | US | disclosed |
| US-7727739-B2 | Methods for measuring enzyme activity | GE HEALTHCARE UK LIMITED (GB) | 2010-06-01 | — | — | US | disclosed |
| US-7335771-B2 | Quinacridone derivatives as labelling reagents for fluorescence detection of biological materials | GE HEALTHCARE UK LIMITED (GB) | 2008-02-26 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070184429-A1 | Method for measuring aromatase activity | GE HEALTHCARE UK LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| EP-1649283-A2 | METHOD FOR MEASURING AROMATASE ACTIVITY | GE Healthcare UK Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012901-A2 | METHOD FOR MEASURING AROMATASE ACTIVITY | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110014641-A1 | METHOD FOR MEASURING AROMATASE ACTIVITY | CYP19A1, CYP17A1, CYP21A2 | MEN1 1057/4885KMT2A 515/4885KDM4E 751/4885 |
| US-20070184429-A1 | Method for measuring aromatase activity | CYP19A1, CYP17A1, CYP21A2 | MEN1 1057/4885KMT2A 515/4885KDM4E 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.