SCHEMBL9512733

SCHEMBL9512733

COC(=O)COc1ccc(C(C)CNS(=O)(=O)c2ccccc2)cc1F

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GRIA4 P48058 1/20 0.53
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
GAA P10253 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
MAPT P10636 2/20 0.45
TSHR P16473 2/20 0.44
HTT P42858 1/20 0.44
ALDH1A1 P00352 2/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
POLB P06746 1/20 0.42
KDM4E B2RXH2 1/20 0.41
FFAR1 O14842 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PKM P14618 1/20 0.40
MAPK1 P28482 1/20 0.40
MEP1B Q16820 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9510499 0.91 GRIA4 (0.55) GRIA4KMT2AFFAR1L3MBTL1PKM
SCHEMBL9510526 0.85 GRIA4 (0.60) GRIA4KMT2AGAASMN1; SMN2MAPT
SCHEMBL10708827 0.83 FFAR1 (0.49) GRIA4KMT2AMEN1TSHRALDH1A1
SCHEMBL9510778 0.82 PTGDR2 (0.51) GRIA4TSHR
SCHEMBL27691417 0.81 GRIA4 (0.54) GRIA4KMT2AGAASMN1; SMN2MAPT
SCHEMBL9510810 0.79 CA1 (0.46) KMT2AMEN1SMN1; SMN2MAPTTSHR
Hydrochloric Acid SCHEMBL9510464 0.78 ALDH1A1 (0.43) KMT2AMEN1GAASMN1; SMN2MAPT
SCHEMBL9512739 0.76 MEN1 (0.44) KMT2AMEN1GAASMN1; SMN2MAPT
SCHEMBL9514108 0.74 FFAR1 (0.50) SMN1; SMN2ALDH1A1POLBFFAR1L3MBTL1
SCHEMBL9765332 0.73 SMN1; SMN2 (0.58) GRIA4GAASMN1; SMN2MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0325245-B1 Phenoxyacetic acid derivatives, preparation thereof, pharmaceutical compositions comprising them and use TANABE SEIYAKU CO (JP) 1993-10-20 EP disclosed
US-4948810-A PLATELET AGGREGATION INHIBITORS TANABE SEIYAKU CO., LTD. (JP) 1990-08-14 US disclosed
EP-0325245-A1 Phenoxyacetic acid derivatives, preparation thereof, pharmaceutical compositions comprising them and use TANABE SEIYAKU CO., LTD. (JP) 1989-07-26 EP disclosed