Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.60 |
| ▸ | GPR183 | P32249 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513181 | 1.00 | THRB (0.73) | THRBHSP90AA1MEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL9516740 | 0.99 | THRB (0.71) | THRBHSP90AA1MEN1KMT2AKCNH2 | |
| SCHEMBL9513241 | 0.93 | THRB (0.82) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9513154 | 0.93 | MEN1 (0.68) | THRBMEN1KMT2AKCNH2PRKAA2 | |
| SCHEMBL10901582 | 0.88 | THRB (0.74) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9512997 | 0.87 | THRB (0.73) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9136775 | 0.87 | THRB (0.73) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9426176 | 0.87 | MEN1 (0.60) | THRBMEN1KMT2AKCNH2PRKAA2 | |
| SCHEMBL10898714 | 0.87 | THRB (0.73) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9515645 | 0.86 | THRB (0.72) | THRBMEN1KMT2AKCNH2PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |