Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.61 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.61 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.61 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.61 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.61 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9514281 | 0.99 | THRB (0.70) | THRBSIGMAR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL9513241 | 0.90 | THRB (0.82) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9514284 | 0.86 | LMNA (0.61) | THRBMGLLMEN1KMT2AKCNH2 | |
| SCHEMBL9513181 | 0.86 | THRB (0.73) | THRBPRKAA2MEN1KMT2AKCNH2 | |
| SCHEMBL9513345 | 0.86 | THRB (0.73) | THRBPRKAA2MEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL9514278 | 0.85 | LMNA (0.60) | THRBPRKAB2PRKAG1PRKAA2PRKAA1 | |
| Hydrochloric Acid SCHEMBL9516740 | 0.85 | THRB (0.71) | THRBPRKAA2MEN1KMT2AKCNH2 | |
| SCHEMBL10901582 | 0.85 | THRB (0.74) | THRBSIGMAR1MEN1KMT2AKCNH2 | |
| SCHEMBL10898714 | 0.84 | THRB (0.73) | THRBMEN1KMT2AKCNH2GPR183 | |
| SCHEMBL9512997 | 0.84 | THRB (0.73) | THRBMGLLMEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |